Stereoselective drug disposition: potential for misinterpretation of drug disposition data.
نویسندگان
چکیده
منابع مشابه
Drug Disposition in Pediatric Patients
The clinical responses to drug administration can be greatly influenced both by the chronological age of the patient and by the relative maturity of the particular organ system that is being targeted. Human development follows a continuum of time-related events. There are unique therapeutic differences and concerns associated with the treatment of the very young and the elderly patient. Age-dep...
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Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men ...
متن کاملGenetic differences in drug disposition.
Genetic polymorphisms of drug metabolizing enzymes are well recognized. This review presents molecular mechanisms, ontogeny and clinical implications of genetically determined intersubject variation in some of these enzymes. Included are the polymorphic enzymes N-acetyl transferase, cytochromes P4502D6 and 2C, which have been well described in humans. Information regarding other Phase I and Pha...
متن کاملPharmacokinetics, Pharmacodynamics, and Drug Disposition
During the last decade, the application of pharmacokinetic and pharmacodynamic modeling techniques has become an increasingly important aspect of contemporary clinical psychopharmacology (1–5). These techniques have been applied during the process of development of new drug entities as well as for the improved understanding of the clinical actions of drugs that are already marketed. Techniques ...
متن کاملPharmacogenomics--drug disposition, drug targets, and side effects.
From St. Jude Children’s Research Hospital and the University of Tennessee Colleges of Pharmacy and Medicine, Memphis (W.E.E.); and Washington University Medical School, St. Louis (H.L.M.). Address reprint requests to Dr. Evans at St. Jude Children’s Research Hospital, 332 N. Lauderdale St., Memphis, TN 381010318, or at [email protected]. t is well recognized that different patients resp...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1988
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1988.tb05318.x